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accession-icon GSE39042
Expression data from MDA-MB-231 cells exposed to hypoxia and/or paclitaxel or epirubicin
  • organism-icon Homo sapiens
  • sample-icon 18 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Hypoxia protects cancer cells from chemotherapeutic drug-induced cell death.

Publication Title

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells.

Sample Metadata Fields

Cell line

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accession-icon GSE21364
mRNA expression data from keratinocytes with disorganized lipid raft structures (by cholesterol depletion by methyl-beta-cyclodextrin)
  • organism-icon Homo sapiens
  • sample-icon 9 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Lipid rafts are cholesterol-rich cell signaling platforms and their physiological role can be explored by cholesterol depletion. To dress a global picture of transcriptional changes ongoing after lipid raft disruption, we performed whole-genome expression profiling in epidermal keratinocytes, a cell type which synthesizes its cholesterol in situ.

Publication Title

Transcriptional profiling after lipid raft disruption in keratinocytes identifies critical mediators of atopic dermatitis pathways.

Sample Metadata Fields

Specimen part, Time

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