mRNA expression pattern of KrasG12D mice with acute pancreatitis compared with wild-type mice without acute pancreatitis

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GSE77983

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

Transgenic KrasG12D mice can recapitulate pancreas intra-epithelial neoplasia (PanIN). Caerulein is a cholecystokinin analogue and induces acute pancreatitis when injected intra-abdominally. Caerulein-induced acute pancreatitis will accelerate PanIN progression in KrasG12D mice. We compared mRNA profile changes between KrasG12D mice with acute caerulein-induced pancreatitis and wild-type mice without acute pancreatitis.

PubMed ID

27009811

Publication Title

Challenges in detecting pre-malignant pancreatic lesions during acute pancreatitis using a serum microRNA assay: a study based on KrasG12D transgenic mice.

Total Samples

Submitter’s Institution

Peking Union Medical College Hospital

Authors

Hong X, Zhang J, Wu Q, Wang W, Ye AY, Song W, Dai H, Wang X, Wu F, You L, Wu W, Zhao Y

Source Repository

Gene Expression Omnibus (GEO)

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