Transcription profling by array of 15 untreated paediatric T-cell acute lymphoblastic leukaemia cell lines to identify genes associated with drug resistance

Baseline glucocorticoid resistance profiles were measured in a panel of 15 paediatric T-Cell acute lymphoblastic leukaemia cell lines and correlated with Affymetrix Gene expression to identify genes and pathways associated with drug resistance in T-ALL. The cell lines' resistance to Methylprednisolone (MPRED) and Dexamethasone (DEX) was then tested using the MTT assay and IC50 values (drug concentration lethal to 50% of cells) for each drug were calculated.

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